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apalutamide will lower the extent or effect of ethinylestradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medication that are CYP3A4 substrates can lead to reduce publicity to these prescription drugs.armodafinil will lower the level